Diagnosis And Treatment
Comprehensive Evaluation for Diagnosis and Treatment of Chronic Diseases
Data from the 2018 National Health Interview Survey (NHIS) showed that more than half (51.8%) of US adults had at least 1 of 10 selected diagnosed chronic conditions (arthritis, cancer, chronic obstructive pulmonary disease, coronary heart disease, current asthma, diabetes, hepatitis, hypertension, stroke, and weak or failing kidneys), and 27.2% of US adults had multiple chronic conditions.
Chronic inflammation is the driving force behind most chronic diseases.
Inflammation gradually weakens the immune system, making it increasingly more vulnerable to the development of chronic illnesses. By decreasing risk factors and harnessing the power of the human immune system, inflammation can be decreased, new cells can be generated and the body can function better.
Critical to assessing a patient’s health status is having all of the medical, lifestyle and environmental information which are associated with chronic diseases.At The Maharaj Institute we offer a comprehensive Wellness and Anti-Inflammatory Program which is specifically designed to address the patient’s issues.
Dr. Maharaj is a leader in the diagnosis and management of blood diseases (malignant and non-malignant) with more than 30 years of experience in the field of Internal Medicine,Hematology/Oncology/Immunology and Bone Marrow Stem Cell Transplantation.
Patients with hematological malignancies and immune dysfunction are at a particularly higher risk of developing severe infections.
At the Maharaj Institute, our focus and treatment plans are designed to decrease or prevent infections in at-risk patients.The outpatient approach has resulted in a decreased incidence of infections,improved survival and overall quality of life of our patients.
Our experienced and caring team treat patients with the following hematological malignancies on a fully outpatient basis:
The Institute offers excellent service and care for non-malignant hematological diseases such as:
Second Option Consultations
The Maharaj Institute provides second opinion consultations for those individuals who wish to get a detailed understanding of their condition and available treatment options. In this highly specialized consultation, medical records are extensively reviewed prior to a comprehensive clinical evaluation. It is a very personalized and precision approach which is unique to the Maharaj Institute.Standard of care as well as available investigational treatments, are carefully explained to the patient and family members, helping them in the decision making process of what is best for the patient.
Our patient navigators work closely with the patient and family to ensure that medical records are provided in a timely-manner prior to the consultation.
Bone Marrow Aspiration and/or Biopsy under Conscious Sedation
A bone marrow aspiration and biopsy is a common procedure used for the diagnosis and follow up treatment of many blood diseases and other conditions that affect the bone marrow. A sample of the liquid and solid portion of the bone marrow is removed and then submitted to a pathologist and/or a laboratory for examination.
At the Maharaj Institute the bone marrow biopsy is done under conscious sedation. Patients are given pain relievers and sedatives prior to the monitored procedure with the goal of ensuring a pain-free experience. Patients are closely monitored to prevent complications and discharged with a caregiver after full recovery.
Immunotherapy and Targeted Therapies
Immunotherapy is a type of treatment designed to boost the body’s natural defenses to fight cancer and other diseases with immune dysfunction.
Immunotherapy may work in the following ways:
Immunotherapy is a broad category of anti-cancer treatment which can be grouped into four different subcategories:
Plasmapheresis
Blood plasma may contain antibodies that attack the immune system and impair its ability to function properly. Removal of those antibodies from the plasma can be highly effective in the treatment of certain diseases.Plasmapheresis is a process in which the plasma—the liquid part of the blood—is separated from the blood cells in a machine and replaced with a solution, such as saline or albumin, which is then infused back into the patient.
Plasmapheresis can be used to treat a variety of disorders including: myasthenia gravis, Guillan-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, Lamber-Eaton myasthenic syndrome, certain forms of neuropathies, and thrombotic thrombocytopenic purpura.
Treatment frequency can vary widely depending on the patient’s overall clinical condition.
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Infusion Services
At the Maharaj Institute, a patient can receive intravenous infusions, safely, in one of our private rooms, without the inconvenience and risks associated with having to go to the in-patient hospital.Patients can feel confident, knowing that their physician is always within easy access and that the nurse and pharmacist will carefully monitor the infusion and answer their questions. Our nurses are experienced in administering complex intravenous therapies and our pharmacy follows strict sterile compounding guidelines.
Our Infusion Services include:
- Hydration and electrolyte replacement;
- Antibiotic, antiviral and antifungal therapies;
- Anti-inflammatory and steroid therapies;
- Micronutrient infusions (e.g. Iron)
- Specialty infusions.
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Transfusion Services
A blood transfusion is a routine medical procedure that can be lifesaving for many patients. During a blood transfusion, donated blood or blood products are given to the patient intravenously.Common indications for blood transfusions are:
- Post chemotherapy and bone marrow transplantation;
- Bleeding disorders;
- Surgery and injuries.
At the Maharaj Institute, a patient can receive blood transfusions safely in one of our private rooms, without the inconvenience and risks associated with going to the in-patient hospital.
Our experienced clinical staff gives intravenous injections prior to the transfusion to avoid transfusion reactions, performs safety identification checks of the blood product and monitors the patient throughout the procedure. A physician is always within easy access in the event a patient develops any sign of transfusion reaction or has any issues, questions or concerns.
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Pharmacy Services
The Maharaj Institute has a State of Florida certified pharmacy that follows strict compounding standards issued by the United States Pharmacopeia (USP) Chapter 797 which ensures the preparation of sterile compounds.Our pharmacy dispenses medications and infusions based on evidence-based guidelines for quality and efficacy in-patient care. The Institute strives to educate patients on the safety and efficacy of medications.
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Clinical Trials
The Maharaj Institute has FDA IND clinical trial research protocols for:1. Aging of the immune system/Immune Senescence
PROTOCOL 001.16-BMSCTI: “Phase 1/2 Clinical Study Evaluating the Safety and Efficacy of Fresh Frozen Plasma (GMFFP) from young healthy donors ages 18 to 35, who have received Granulocyte – Colony Stimulating Factor (G-CSF) to Ameliorate Frailty and Enhance the Immune Risk Profile in Older Individuals”
The primary purpose of this study is to determine the safety and tolerability of 12, once monthly transfusions of Granulocyte – Colony Stimulating Factor (G-CSF) Mobilized Fresh Frozen Plasma (GMFFP) harvested from young, healthy donors and given to older, frail individuals who are at risk due to unhealthy aging and who will then have a subsequent 12-month follow-up period. The secondary objective is to determine the efficacy in older, frail individuals of 12, once monthly transfusions of GMFFP (Granulocyte – Colony Stimulating Factor (G-CSF) Mobilized Fresh Frozen Plasma harvested from young, healthy donors), and a subsequent 12-month follow-up period, to improve the Immune Risk Profile, (“IRP”), cognitive function (MME), quality of life (OPQOL-35), Frailty Index, (“FI”), associated with unhealthy aging in the treated subjects.
2. Solid Tumors/ Cancer
A Phase I/II Study For Use of White Blood Cells From Healthy Donor Participants to Treat Solid Tumors
The primary purpose of this study is to determine the safety of White Cell Transfer (WCT), i.e. intravenous infusion given from HLA-mismatched healthy donors. The secondary objective of this study is to determine the efficacy of White Cell Transfer in terms of disease response, i.e. complete response, partial response, stable disease, and progressive disease.
This investigational new cancer therapy was developed from the laboratory research done by Dr. Zheng Cui MD., Ph.D. who identified that a particular strain of lab mouse (SR/CR mice) was cancer resistant. Dr. Cui’s research concluded that the cancer resistance was mediated by a specific population of leukocytes (granulocytes and monocytes) and that these cells, when transfused to a mouse with cancer, would result in complete remission of the cancer.
The aim of this clinical trial is to replicate in humans the same results observed in mice and, ultimately, lead to an effective, nontoxic treatment for newly diagnosed patients as well as patients who can no longer benefit from conventional treatments.
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